Paul Rudd (George Gergenblatt), Jennifer Aniston (Linda Gergenblatt), Justin Theroux (Seth), Malin Akerman (Eva), Lauren Ambrose (Almond), Joe Lo Truglio (Wayne Davidson), Alan Alda (Carvin), Kathryn Hahn (Karen), Ken Marino (Rick), Michaela Watkins (Marissa), Ian Patrick (Grisham), John D'Leo (Tanner), David Wain (er selbst), Michael Showalter (er selbst), Michael Ian Black (er selbst), Zandy Hartig (Marcy), Keegan Michael Key (Marcys Flunkie), Mather Zickel (Jim Stansel), Juan Piedrahita (Paco), Martin Thompson (Dale), Peter Salett (Manfreddie), Patricia French (Beverly), Juana Samayoa (Stephanie Davis), Jim Moffatt (Tony Piloski), Kerri Kenney (Kathy), Jordan Peele (Rodney), Linda Lavin (Shari), Jessica St. Clair (Deena Schuster), Todd Barry (Sherm)