Patrick Stewart (Captain Jean-Luc Picard), Jonathan Frakes (Commander William T. Riker), Brent Spiner (Lieutenant Commander Data / B-4), Michael Dorn (Lieutenant Commander Worf), Levar Burton (Lietenant Commander Geordi La Forge), Marina Sirtis (Counselor Deanna Troi), Gates McFadden (Dr. Beverly Crusher), Tom Hardy (Shinzon), Ron Perlman (Vizekönig Vkruk), Dina Meyer (Commander Donatra), Kate Mulgrew (Admiral Kathryn Janeway), Whoopi Goldberg (Guinan), Shannon Cochran (Senator Tal'aura), Jude Ciccolella (Commander Suran), Alan Dale (Prätor Hiren), Wil Wheaton (Wesley Crusher), David Ralphe (Commander), J. Patrick McCormack (Commander), Bryan Singer (Kelly)