Dylan O'Brien (Thomas), Thomas Brodie-Sangster (Newt), Ki Hong Lee (Minho), Kaya Scodelario (Teresa), Giancarlo Esposito (Jorge), Jacob Lofland (Aris), Rosa Salazar (Brenda), Aidan Gillen (Janson), Dexter Darden (Pfanne), Patricia Clarkson (Ava Paige), Lili Taylor (Mary Cooper), Nathalie Emmanuel (Harriet), Lora Martinez-Cunningham (Thomas' Mutter), Katherine McNamara (Sonya), Matthew Page (Harold (Soldat)), Barry Pepper (Vince), David House (Soldat), Alan Tudyk (Marcus), Jenny Gabrielle (Ponytail), Tatanka Means (Joe), Morse Bicknell (Doktor), Matthew T. Metzler (Barkley), Luke Gallegos (junger Thomas), James Burnett (Rebellenposten), Ryan Jason Cook (Schwester), Alexander Flores (Winston), John Trejo (M3-Soldat), Brandon K. Hampton (Beobachter im Überwachungsraum), Kathryn Smith-McGlynn (Dr. Crawford), Alex Knight (Helfer), Terry Dale Parks (Carl), Jeremy Becerra (Riley), Shawn Prince (David), Marc Comstock (Medizintechniker)