Naomi Watts (Ann Darrow), Jack Black (Carl Denham), Adrien Brody (Jack Driscoll), Thomas Kretschmann (Captain Englehorn), Colin Hanks (Preston), Andy Serkis (Kong / Lumpy), Evan Parke (Mr. Hayes), Jamie Bell (Jimmy), Kyle Chandler (Bruce Baxter), David Pittu (Mr. Weston), Craig Hall (Mike, der Tontechniker), John Sumner (Herb, der Kameramann), Tiriel Mora (Fruchtverkäufer), Jed Brophy (Matrose), Jim Knobeloch (rauhbeiniger Manager), Ric Herbert (schmieriger Manager), Tom Hobbs (junger Assistent), Lee Donahue (Studioassistent), Lobo Chan (Choy), Pip Mushin (Zelman), William Johnson (Manny), Mark Hadlow (Harry), Geraldine Brophy (Maude), David Denis (Taps), Frank Edwards (Matrose)