Tom Hanks (James B. Donovan), Mark Rylance (Rudolf Abel), Victor Verhaeghe (Agent Gamber), Amy Ryan (Mary Donovan), Sebastian Koch (Wolfgang Vogel), Brian Hutchison (FBI-Agent), Billy Magnussen (Doug Forrester), Alan Alda (Thomas Watters Jr.), Scott Shepherd (Hoffman), Joshua Harto (Bates), Austin Stowell (Francis Gary Powers), Eve Hewson (Jan Donovan), Jesse Plemons (Joe Murphy), Stephen Kunken (William Tompkins), Michael Schenk (Cousin Drews), Michael Gaston (Agent Williams), Peter McRobbie (Allen Dulles), Nadja Bobyleva (Katje), Burghart Klaußner (Harald Ott), Domenick Lombardozzi (Agent Blasco), Mikhail Gorevoy (Ivan Schischkin), Max Mauff (Otts Sekretär), Will Rogers (Frederic Pryor), Dakin Matthews (Richter Byers), Noah Schnapp (Roger Donovan), Rebekah Brockman (Alison - Donovans Sekretärin), Michael Pemberton (Lügendetektorexperte), Henny Russell (Rezeptionist), Michael Kempen (Pilot im Motelzimmer), Geoffrey Rude (Pilot im Motelzimmer), Jillian Lebling (Peggy Donovan), John Rue (Lynn Goodnough), Petra Marie Cammin (Helen Abel), Joel Brady (Polizist im Brooklyn Courthouse), Mark Fichera (FBI-Agent)