Will Smith (Detective Mike 'Eugene' Lowrey), Martin Lawrence (Detective Marcus Burnett), Jordi Mollà (Hector Juan Carlos 'Johnny' Tapia), Gabrielle Union (Sydney 'Syd' Burnett), Peter Stormare (Alexei), Theresa Randle (Theresa Burnett), Joe Pantoliano (Captain C. Howard), Oleg Taktarov (Josef), Jon Seda (Roberto), Michael Shannon (Floyd Poteet), John Salley (Fletcher), Jason Manuel Olazabal (Detective Marco Vargas), Yul Vazquez (Detective Mateo Reyes), Otto Sanchez (Carlos), Henry Rollins (TNT-Anführer), Antoni Corone (DEA-Agent Tony Dodd), Gary Nickens (TNT-Mann Fanuti), Rey Hernandez (TNT-Mann Zank), Charlie Johnson (TNT-Mann Lockman), Paul Villaverde (TNT-Mann Dexter), Reynaldo Gallegos (Tito Vargas), Veryl Jones (DEA-Agentin Taylor), Tim Powell (DEA-Agent Snell), Phil Owens (AC DEA), Timothy Adams (DEA-Agent im Van), Keith Hudson (DEA-Agent), Rich Kelley (DEA-Agent), Dave Corey (FBI-Agent Eames), Bill Erfurth (Alpha 12), David Combe (Lupe), R.E. Rodgers (Delongpre), Chris Charles Herbert (Funker der Küstenwache), Nelson J. Perez (Captain der Küstenwache), Bobby Talbert (AWAC-Techniker), Nancy Duerr (Marcus' Polizeipsychologin), Ivelin Giro (Mikes Polizeipsychologin), Damaris Justamante (Gruppentherapeut), Bill Cordell (Arzt), Alex Warren (medizinischer Experte), Dennis Greene (Reggie), Bianca Bethune (Megan Burnett)